Breaking: Government Trial Shows Efficacy for Remdesivir in COVID Infection

A placebo-controlled, government run trial of remdesivir to treat COVID-19 infection reportedly met its “primary efficacy endpoint” according to Gilead Sciences. While we are waiting for more information on the results, having shown efficacy in this large (800 patient), controlled trial could help to resolve the questions raised in prior testing of the drug. MoreContinue reading “Breaking: Government Trial Shows Efficacy for Remdesivir in COVID Infection”

Sweden May Show the US the Way Forward

As we try to extract ourselves from lockdown, one approach to move forward is based on Sweden’s response to the pandemic. For those who haven’t heard of Sweden’s approach, they are not doing universal social distancing, did not close down any businesses, and did not cancel any large events. Sweden’s plan was crafted by theirContinue reading “Sweden May Show the US the Way Forward”

NYC Passes the 25% Threshold While Anti-IL6 Results Confound

The latest COVID-19 figures from NYC are in and they are as impressive as the Skyline! Governor Cuomo announced that 25% of NYC residents are positive on COVID antibody (blood) testing, while 15% of NY State residents are positive. This means that when the blood test was done, 25% of NYC residents and 15% ofContinue reading “NYC Passes the 25% Threshold While Anti-IL6 Results Confound”


Summary: Almost everyone hospitalized with COVID-19 has a pre-existing health problem! One of the things I find most frustrating is how the news media has not accurately portrayed the health risks from COVID-19. It seems there is an ongoing effort to scare the general population about their risk of getting sick and dying from COVID-19.Continue reading “IN REALITY, WHO GETS SICK FROM COVID?”

Wonderful News From NYC You Don’t See On TV!

In the media’s rush to point out the ongoing problems with COVID-19, they seemed to have missed a major story! These are the daily COVID death and hospitalization statistics from the NYC government website. The Hospitalizations (upper panel) peaked before the Deaths (lower panel), which is not surprising because most individuals are sick for someContinue reading “Wonderful News From NYC You Don’t See On TV!”

Biscuit returns, albeit a bit hoarse…

Biscuit and Nindy return to talk about their dumbest COVID-19 ideas of the week. Nindy had to do most of the talking though since Biscuit tried to drink the Lysol. Poor dog just believes everything he hears on TV…. 1) Underestimating COVID-19 infection rates. Infection rates have been remarkably underestimated, which gives people a false senseContinue reading “Biscuit returns, albeit a bit hoarse…”

Whipsawed by Remdesivir

In the last few weeks we have been given bizarrely conflicting information about the use of remdesivir to treat COVID-19 infection. This antiviral drug appeared to have the most promise to treat COVID-19, as it demonstrated a well-defined mechanism of action specific for the virus. It also had shown some efficacy in other, similar viralContinue reading “Whipsawed by Remdesivir”

Thursday night news we might not want…

Two pieces of news tonight. A preliminary Chinese study that was accidentally leaked by the WHO suggested that remdesivir was not effective in treating COVID-19 patients. STAT News found the study on the WHO website , and it undercuts the hope that this antiviral drug might be useful in treating COVID-19. Like many of theContinue reading “Thursday night news we might not want…”

Why COVID-19 antibody assays can be unreliable.

As discussed in the blog post yesterday, the COVID-19, lateral flow antibody test is a remarkably simple, very stable and consistent platform. It requires no machine to run, it can be stored at up to 86°F for up to a year, and as long as the reagents are unused it gives very consistent results. DespiteContinue reading “Why COVID-19 antibody assays can be unreliable.”

How COVID-19 Antibody Tests Work

Most COVID-19 antibody tests available to use outside a laboratory involve “lateral flow assays” named because they use diffusion of serum antibodies laterally in a paper strip. Blood or serum is placed at one end of the strip, and if it binds to a gold nanoparticle coupled to coronavirus proteins the nanoparticle is captured atContinue reading “How COVID-19 Antibody Tests Work”