AstraZeneca’s COVID-19 vaccine study is put on hold. My preference is not to take this vaccine regardless of the outcome.

Tonight, AstraZeneca announced that its COVID-19 vaccine study was put on hold due to a suspected reverse reaction in a trial participant in the United Kingdom. This event has triggered me to write more specifically about COVID-19 vaccines. I have purposely withheld my personal commentary on the relative benefits of the different COVID-19 vaccines, although I haveContinue reading “AstraZeneca’s COVID-19 vaccine study is put on hold. My preference is not to take this vaccine regardless of the outcome.”

Ventilation, the forgotten protection for children in their school classes.

In honor of the first day of school in Michigan tomorrow, I wanted to bring attention to an article in the Wall Street Journal that reinforces an important concept for COVID-19 safety in classrooms. It is that by simply increasing ventilation and airflow in classrooms, respiratory clouds that contain the SARS-CoV-2 virus can be disrupted before theyContinue reading “Ventilation, the forgotten protection for children in their school classes.”

Cellular immune problems are why young people can die from COVID-19

One of the most disturbing problems in COVID-19 medicine care has been that a few young people have become extremely ill with this infection. While these cases are rare, they unnerve physicians because the patients have not had the chronic Illnesses that predispose most people to serious COVID-19 infections. Many of us have thought thatContinue reading “Cellular immune problems are why young people can die from COVID-19”

We finally get to see the results of early clinical trials of the Russian COVID-19 vaccine, and they look OK.

On Friday, the medical Journal Lancet published the results of the first clinical trials involving the Russian COVID-19 vaccine.  As background, the Russian vaccine (nicknamed Sputnik V after the famous satellite) is made from a recombinant virus that causes human colds upper respiratory infections (adenovirus) that has been genetically modified to produce the spiked protein from theContinue reading “We finally get to see the results of early clinical trials of the Russian COVID-19 vaccine, and they look OK.”

What drives severe disease in COVID-19 patients?

I have received a number of inquiries from people who’ve identified a recent article suggesting that a supercomputer has identified Bradykinin as the central mediator of inflammatory disease associated with COVID-19. I have to say that I’m not impressed by this hypothesis.  This theory proposes that a single molecule, bradykinin, which is involved in opening poresContinue reading “What drives severe disease in COVID-19 patients?”

It’s the NIH vs. the FDA on convalescent plasma treatment of COVID-19!

Last week I used two blog posts to examine the decision by the Food and Drug Administration (FDA) to provide an emergency use approval (EUA) for the treatment of COVID-19 with convalescent plasma. This therapy theoretically uses antibodies from the blood of recovered COVID-19 patients to neutralized and inactivate the SARS-CoV-2 virus in the bloodstream ofContinue reading “It’s the NIH vs. the FDA on convalescent plasma treatment of COVID-19!”

News on the distribution of coronavirus vaccines.

There were two new reports today on plans for the distribution of coronavirus vaccines once they are approved. The first came from the United States National Academies Advisory Group, which was developed specifically to address the distribution issue. It addresses some very important issues on the distribution of the vaccines and prioritizing which individuals get theContinue reading “News on the distribution of coronavirus vaccines.”

Another preliminary report on COVID-19 re-infection.

Another case of a recurrent infection with COVID-19 has been reported. This case was similar to the Hong Kong case in that the secondary infection was identified because the viruses from these patients were both amplified by PCR and sequenced and found to be different from the virus initially isolated when the patient first hadContinue reading “Another preliminary report on COVID-19 re-infection.”

Biscuit’s best coronavirus job opportunities!

Biscuit recently heard that dogs were being trained to sniff out the coronavirus in human saliva. He thought this was a real opportunity for him to get out of the house and get a job! His nose is actually much larger and more useful than any other part of his body. He also can sniff some ofContinue reading “Biscuit’s best coronavirus job opportunities!”