Eight things not to worry about this Father’s Day!

I wanted to wish everyone a happy Father’s Day from pandemic pondering! As I said on Mother’s Day, the one most positive aspects of the “stay at home orders” was having my daughter back with us. Hopefully all fathers can look back on this episode and remember bonding with our young adult children as theyContinue reading “Eight things not to worry about this Father’s Day!”

Projections and modeling of the COVID-19 pandemic

One of the most contentious issues that has emerged in COVID-19 debate is the inaccuracy of statistical modeling of the infection. This has been exacerbated by a very contentious debate on how individuals in the public health community should frame disagreements about predictions are the COVID-19 epidemic.  Two recent articles have highlighted this debate. An editorialContinue reading “Projections and modeling of the COVID-19 pandemic”

Yes the COVID-19 news is confusing!

On CNN.com the headline reads… COVID-19 trends from the NYT and in Florida, there is concerning news….. Looking at the actual numbers does not seem to indicate a big change? But, someone is finally trying to help Florida! The CDC has released a guidance aimed at government controlled and private beaches to help protect lifeguards and sunbathersContinue reading “Yes the COVID-19 news is confusing!”

Three important updates.

The FDA announced yesterday that hydroxychloroquine had a negative drug interaction with remdesivir, the only antiviral drug that showed activity with the SARS-CoV-2 virus. The reaction was severe enough that it negated the benefit of remdesivir for treating COVID-19.  This finding helped clarify why the FDA removed the emergency use authorization for hydroxychloroquine, since taking theContinue reading “Three important updates.”

Dexamethasone: Another turning point in the COVID-19 pandemic, or another colossal disappointment?

Today a press release was posted that claimed the use of the generic, anti-inflammatory corticosteroid dexamethasone could reduce mortality from severe COVID-19 lung infection by 1/3. This was remarkable given that this drug is well known and already available in large supply. It would cost less than $50 for a course of treatment. The sideContinue reading “Dexamethasone: Another turning point in the COVID-19 pandemic, or another colossal disappointment?”

The end of the line for hydroxychloroquine for COVID-19.

Today, the FDA removed the Emergency Use Authorization supporting the use of hydroxychloroquine treatment or prophylaxis for COVID-19 infection. None of the multiple clinical studies involving the drug has shown any efficacy in treating or preventing COVID-19. While cardiac toxicity was a concern, no study suggested that was the defining issue. The most important thingContinue reading “The end of the line for hydroxychloroquine for COVID-19.”

A press release suggests functional activity for the SARS-CoV-2 substitution D614G

Today several news outlets highlighted a new report suggesting a single amino acid change in the spike protein of SARS-CoV-2 that could alter viral infectivity. This substitution changes the amino acid at position 614 of the viral spike protein from an aspartic acid (D) to a glycine (G).  The D614G virus, as it is identified,Continue reading “A press release suggests functional activity for the SARS-CoV-2 substitution D614G”

Life moves on but Biscuit is still stuck in his routine…

Biscuit is back in this week and is depressed by a number of really bad ideas that have even him confused. A lot of them relate to things like financial issues and political concerns, which don’t impress Biscuit much. He’s more interested in the reports of food shortages, restaurant closings, and why his vet andContinue reading “Life moves on but Biscuit is still stuck in his routine…”

WSJ editorial points out fallacy of the COVID-19 “spike.”

I did not expect to repeat this topic again, but the WSJ had an editorial today pointing out the disconnect between news headlines and political statements touting a resurgent coronavirus wave and the reality of the infection found in public health system numbers. The editorial is written from an economic perspective, however understanding the actualContinue reading “WSJ editorial points out fallacy of the COVID-19 “spike.””